A method for evaluating the hemostatic effect of various agents in thrombocytopenic rats and mie.
نویسندگان
چکیده
By B. G. FIRKIN,#{176} GRACE ARIMURA AND W. J. HAIIRINGTON C LINICAL STUDIES have suggested that certain materials may be useful as platelet substitutes in thrombocytopenia.1 The following investigation was undertaken to devise an experimental model for initial evaluation of these agents. Thrombocytopenia was induced in rats and mice; following severance of the tips of their tails, the blood loss was measured under controlled conditions and compared with the blood loss in normal animals similarly tested. Various substances claimed to be of value in the treatment of thrombocytopenic states were evaluated. Only viable platelets were shown to be effective.
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ورودعنوان ژورنال:
- Blood
دوره 15 شماره
صفحات -
تاریخ انتشار 1960